Medicinal Plant-derived Phytochemicals in Detoxification

• Published in: Current pharmaceutical design Vol. 30; no. 13; p. 988
• Main Authors: Bjørklund, Geir, Cruz-Martins, Natália, Goh, Bey Hing, Mykhailenko, Olha, Lysiuk, Roman, Shanaida, Mariia, Lenchyk, Larysa, Upyr, Taras, Rusu, Marius Emil, Pryshlyak, Antonina, Shanaida, Volodymyr, Chirumbolo, Salvatore
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01-01-2024
• Subjects: Animals; Humans; Inactivation, Metabolic; Phytochemicals - chemistry; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Phytotherapy; Plants, Medicinal - chemistry; Medicinal plants; bioactive natural compounds; detoxifying agents; phytotherapy; hepatoprotection; mechanisms of action
• ISSN: 1873-4286
• DOI: 10.2174/1381612829666230809094242

The average worldwide human life expectancy is 70 years, with a significantly higher value in Western societies. Many modern diseases are not associated with premature mortality but with a decreased quality of life in aged patients and an excessive accumulation of various toxic compounds in the human body during life. Today, scientists are especially interested in finding compounds that can help increase a healthy lifespan by detoxifying the body. Phytotherapy with specific approaches is used in alternative medicine to remove toxins from the body. Worldwide, research is conducted to identify medicinal plant-derived molecules that, with few or no side effects, may protect the liver and other organs. This review provides updated information about the detoxification process, the traditional and modern use of the most effective medicinal plants, their active metabolites as detoxifying agents, and the mechanisms and pathways involved in the detoxification process. Among medicinal plants with substantial detoxifying properties, a major part belongs to the
. The most widely used hepatoprotective phytocomponent is silymarin, a standardized extract from the
seeds containing a mixture of flavonolignans. Many polysaccharides, polyphenols, and terpenoids have a detoxifying effect. Overall, scientific data on medicinal plants used in phytotherapeutic practice worldwide provides an understanding and awareness of their efficacy in detoxification.