Regulation of COX-2 transcription in a colon cancer cell line by Pontin52/TIP49a

Cyclooxygenase-2 (COX-2) is expressed early in colon carcinogenesis and is known to play a crucial role in the progress of the disease. Here we show that the regulation of the expression of this enzyme in a colon cancer cell line, and in patients, is associated with overexpression of the Wnt pathway...

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Bibliographic Details
Published in:	Molecular cancer Vol. 2; no. 1; p. 42
Main Authors:	Carlson, Mary L, Wilson, Ellen T, Prescott, Stephen M
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 15-12-2003 BioMed Central BMC
Subjects:	ATPases Associated with Diverse Cellular Activities Carrier Proteins - genetics Carrier Proteins - metabolism Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Colonic Neoplasms - enzymology Colonic Neoplasms - genetics Colonic Neoplasms - pathology Cyclooxygenase 2 DNA Helicases - genetics DNA Helicases - metabolism Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans In Situ Hybridization Membrane Proteins Prostaglandin-Endoperoxide Synthases - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Short Communication Transcription, Genetic - genetics
Online Access:	Get full text
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