Decrease in human plasma prolactin levels by oral prostaglandin E2 in early puerperium

Eight milligrams of prostaglandin E2 (PGE2; 2 mg every 30 min) were given orally to 12 puerperal women on day 4 after delivery. Plasma levels of prolactin showed a significant decrease in comparison with basal levels and with those of controls sampled over a similar period. The same dose of PGE2 was...

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Bibliographic Details
Published in:	Journal of endocrinology Vol. 87; no. 3; p. 333
Main Authors:	Caminiti, F, De Murtas, M, Parodo, G, Lecca, U, Nasi, A
Format:	Journal Article
Language:	English
Published:	England 01-12-1980
Subjects:	Female Humans Postpartum Period - drug effects Pregnancy Prolactin - blood Prostaglandins E - pharmacology
Online Access:	Get more information
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Summary:	Eight milligrams of prostaglandin E2 (PGE2; 2 mg every 30 min) were given orally to 12 puerperal women on day 4 after delivery. Plasma levels of prolactin showed a significant decrease in comparison with basal levels and with those of controls sampled over a similar period. The same dose of PGE2 was ineffective in modifying the plasma prolactin levels in four puerperal women on day 30 after delivery and in four non-pregnant women with normal levels of prolactin. It is suggested that a PGE2-induced decrease in prolactin could be mediated by hypothalamic dopaminergic neurones.
ISSN:	0022-0795
DOI:	10.1677/joe.0.0870333