Verrucous carcinoma arising in an extended giant condyloma acuminatum (Buschke-Löwenstein tumor): a case report and review of the literature

• Published in: Journal of medical case reports Vol. 7; no. 1; p. 273
• Main Authors: Ahsaini, Mustapha, Tahiri, Yasser, Tazi, Mohammed Fadl, Elammari, Jallaledine, Mellas, Soufiane, Khallouk, Abdelhak, El Fassi, Mohammed Jamal, Farih, My Hassan, Elfatmi, Hind, Amarti, Afaf, Stuurman-Wieringa, Roos E
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19-12-2013; BioMed Central
• Subjects: Case Report
• ISSN: 1752-1947; 1752-1947
• DOI: 10.1186/1752-1947-7-273

Verrucous carcinoma of the external genitalia and perianal region is a rare variant of well-differentiated squamous cell carcinoma. It has been reported to have limited metastatic potential.
We report the case of a 54 year-old Moroccan man who presented with locally advanced giant condyloma acuminatum (Buschke-Löwenstein tumor) after prolonged intervals of neglect (approximately 10 years). The disease covered his suprapubic, external genitalia and perianal region. It was locally aggressive with extensive tissue destruction. After a biopsy of the lesion, the diagnosis of verrucous carcinoma was confirmed. He initially received chemoradiotherapy, followed by extensive local excision, but he developed septic shock and died a few days later.
The purpose of this case report is to present a case of verrucous carcinoma arising in an extensive giant condyloma acuminatum (Buschke-Löwenstein tumor) and discuss the literature on its diagnosis and management.