Association of FADS2 rs174575 gene polymorphism and insulin resistance in type 2 diabetes mellitus

• Published in: African health sciences Vol. 20; no. 4; pp. 1770 - 6
• Main Authors: Shetty, Shilpa S, Kumari, Suchetha N, Devi, Harshini, KP, Sharmila, Rai, Srinidhi
• Format: Journal Article
• Language: English
• Published: Kampala, Uganda Makerere University Medical School 01-12-2020; Makerere Medical School
• Subjects: Fatty acid desaturase; gene polymorphism; type 2 diabetes mellitus
• ISSN: 1680-6905; 1680-6905; 1729-0503
• DOI: 10.4314/ahs.v20i4.30

Background: Many risk factors contribute to the pathogenesis of
diabetes. Gene and lifestyle factors are considered to be the major
contributors. A dietary pattern is attributed to be one of the
lifestyle risk factors favoring diabetes. The present study aims to
find an association between fatty acid desaturase (FADS) gene
polymorphism and glycemic profile in type 2 diabetes mellitus (T2DM).
Methodology: A total of 429 subjects were included in the study on the
basis of inclusion and exclusion criteria, of which 213 and 216
subjects were diabetic and control, respectively. Body mass index was
calculated. Fasting plasma glucose, glycated hemoglobin (HbA1c) and
insulin were measured using commercially available kits. rs174575 of
FADS2 was selected based on previous publications and identified using
the dbSNP database. To compare the biochemical parameters with the
genotype, the following three models were used: additive model (CC vs
CG vs GG), dominant model (CC + CG vs GG), and recessive model (CC vs
CG + GG). Results and Discussion: FBS, HbA1c, insulin, HOMA-IR, and
HOMA-B exhibited a high and statistically significant difference
between subjects and controls. The three models exhibited a
statistically significant difference between FBS, HOMA-IR, and HOMA- B
(p<0.05). Conclusion: The distribution of rs174575 genotype differed
significantly between the subjects and controls in the present study.
The study revealed that genetic variation in FADS2 is an additional
facet to consider while studying the risk factors of T2DM.