Can the transition into anoestrus in the ewe be accounted for solely by insufficient tonic LH secretion?

• Published in: Journal of endocrinology Vol. 106; no. 1; p. 55
• Main Authors: Legan, S J, Goodman, R L, Ryan, K D, Foster, D L, Karsch, F J
• Format: Journal Article
• Language: English
• Published: England 01-07-1985
• Subjects: Anestrus; Animals; Estradiol - blood; Estrus; Feedback; Female; Follicle Stimulating Hormone - blood; Luteinizing Hormone - metabolism; Luteolysis; Ovary - physiology; Pregnancy; Progesterone - blood; Seasons; Sheep
• ISSN: 0022-0795
• DOI: 10.1677/joe.0.1060055

It has been proposed that a seasonal increase in oestradiol negative feedback elicits anoestrus by preventing a key step in the preovulatory sequence of endocrine events, namely a sustained increase in tonic LH secretion. In the present study we compared the patterns of serum LH, FSH, oestradiol and progesterone after regression of the last corpus luteum of the breeding season, with their respective patterns during an ovulatory cycle in the late breeding season (samples obtained every 4 h from eight ewes). After regression of the last corpus luteum of the breeding season, serum LH and oestradiol showed distinct deviations from their respective late breeding season patterns. The rise in tonic LH secretion was curtailed. Further, there were no marked increases in oestradiol, despite a distinct, although brief, tonic LH rise; thus there were no gonadotrophin surges. If the hypothesis that the transition into anoestrus is caused solely by insufficient tonic LH secretion were correct, the brief increase in LH should have induced a transient rise in oestradiol. Since this was not the case, these results suggest that a decreased ovarian response to LH may also contribute to the termination of oestrous cyclicity at the transition to anoestrus.