Association of the FcepsilonRIbeta gene with bronchial hyper-responsiveness in an Italian population

A study of two DNA polymorphisms (i2 RsaI, E237G) in the gene for the beta subunit of the IgE high affinity receptor (FcepsilonRIbeta) was performed in 168 Italian families with atopic asthmatic children. The prevalence of the E237G allele in the Italian population was 4%, so this polymorphism was u...

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Bibliographic Details
Published in:	Journal of medical genetics Vol. 35; no. 8; pp. 680 - 681
Main Authors:	Trabetti, E, Cusin, V, Malerba, G, Martinati, L C, Casartelli, A, Boner, A L, Pignatti, P F
Format:	Journal Article
Language:	English
Published:	England BMJ Publishing Group Ltd 01-08-1998 BMJ Publishing Group LTD
Subjects:	Alleles Asthma - genetics Child Deoxyribonucleases, Type II Site-Specific Female Humans Italy Male Pedigree Polymorphism, Genetic Receptors, IgE - genetics Italy
Online Access:	Get full text
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Summary:	A study of two DNA polymorphisms (i2 RsaI, E237G) in the gene for the beta subunit of the IgE high affinity receptor (FcepsilonRIbeta) was performed in 168 Italian families with atopic asthmatic children. The prevalence of the E237G allele in the Italian population was 4%, so this polymorphism was unsuitable for this study. The i2 RsaI polymorphism minor allele frequency was 44%, and it had a PIC value of 0.37. Linkage analysis indicated a significant allele sharing in affected sib pairs for bronchial hyper-responsiveness (BHR, p=0.048), but not for allergic asthma. These data indicate an association of bronchial hyper-responsiveness with the FcepsilonRIbeta gene.
Bibliography:	href:jmedgenet-35-680.pdf local:jmedgenet;35/8/680 ark:/67375/NVC-WMNWVB96-X istex:169D445CA8DA3EBF0519F7DF2A006DCC134FC51B PMID:9719379 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-2593 1468-6244 1468-6244
DOI:	10.1136/jmg.35.8.680