Cell-specific expression of aromatase and LH receptor mRNAs in rat ovary

Current understanding of the endocrine and paracrine regulation of follicular oestrogen synthesis predicts that aromatase cytochrome P450 (P450arom) mRNA is inducible by FSH in granulosa cells. LH receptor mRNA is constitutively expressed in thecal/interstitial cells, and is also thought to be induc...

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Bibliographic Details
Published in:	Journal of molecular endocrinology Vol. 9; no. 3; p. 309
Main Authors:	Whitelaw, P F, Smyth, C D, Howles, C M, Hillier, S G
Format:	Journal Article
Language:	English
Published:	England 01-12-1992
Subjects:	Animals Aromatase - genetics Female Follicle Stimulating Hormone - pharmacology Gene Expression - drug effects Hypophysectomy In Situ Hybridization Ovary - cytology Ovary - drug effects Ovary - metabolism Rats Rats, Wistar Receptors, LH - genetics RNA Probes RNA, Messenger - genetics RNA, Messenger - metabolism
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Summary:	Current understanding of the endocrine and paracrine regulation of follicular oestrogen synthesis predicts that aromatase cytochrome P450 (P450arom) mRNA is inducible by FSH in granulosa cells. LH receptor mRNA is constitutively expressed in thecal/interstitial cells, and is also thought to be induced in granulosa cells in response to joint stimulation by FSH and oestrogen. This study provides direct evidence that FSH induces the ovarian P450arom gene selectively, perhaps exclusively, in the granulosa cells of Graafian follicles. FSH-induction of LH receptor mRNA occurs simultaneously but is independent of oestrogen synthesis per se.
ISSN:	0952-5041
DOI:	10.1677/jme.0.0090309