BALANITES AEGYPTIACA PROTECTION AGAINST PROLIFERATION OF DIFFERENT CANCER CELL LINE

• Published in: African journal of traditional, complementary, and alternative medicines Vol. 13; no. 2; p. 25
• Main Authors: Al-Malki, Abdulrahman L, Barbour, Elie K, Abulnaja, Kalid O, Moselhy, Said S, Kumosani, Taha A, Choudhry, Hani
• Format: Journal Article
• Language: English
• Published: African Ethnomedicines Network 01-01-2016
• Subjects: antiproliferative; apoptosis; Balanites aegyptiaca
• ISSN: 0189-6016; 0189-6016
• DOI: 10.4314/ajtcam.v13i2.2

Backgroud: The aim of the present study was to evaluate in vivo
anti-tumor activity of Balanites aegyptiaca fruits extracts in
addition to its role in cell cycle and apoptosis. Materials and
Methods: Antitumor activities of ethylacetae extract (EAE), ethanol
extract (EE) and chloroform extract (CE) were tested against different
cell line Hep-2, MCF-7, HL-60 and HCV29T. Calculation of the IC50
values for these extracts confirmed that the most potent plant extract
was EAE (40 ug/ml) followed by EE (55ug/ml), CE (61ug/ml). Results: The
ethanolic and chloroform extracts showed lower difference in their
potency, while the EAE was found to be more active indicating for
nonpolar active principles responsible for the anti-proliferative
activity. The ethanolic extract was three times higher active than the
chloroform extract. The results obtained showed that EAE exert a
significant anti-proliferative, enhancement of apoptosis and modulation
of cell cycle phases compared with vincristine. Conclusion: The
presence of alkaloids, flavonoids and Phenolics increase its efficiency
as anti-proliferative action. EAE has promising anti-cancer activity
with higher activity than EE or CE extracts