Mutation c.307G>A in FUT1 gene has no effect on production performance of Yorkshire pigs in the tropics: the case of Vietnam

• Published in: Canadian journal of animal science Vol. 100; no. 3; pp. 426 - 431
• Main Authors: Luc, Do Duc, Thinh, Nguyen Hoang, Bo, Ha Xuan, Vinh, Nguyen Thi, Manh, Tran Xuan, Hung, Nguyen Van, Ton, Vu Dinh, Farnir, Frédéric
• Format: Journal Article Web Resource
• Language: English
• Published: Ottawa Canadian Science Publishing 2020; Canadian Science Publishing NRC Research Press; Agricultural Institute of Canada
• Subjects: Animal production & animal husbandry; Animals; Body weight; diarrhea resistant; E coli; Escherichia coli; FUT1; FUT1 gene; Gene polymorphism; Genotype & phenotype; Genotypes; Life sciences; Meat; Muscles; Mutation; Nucleotides; performance de production; Polymerase chain reaction; Polymorphism; porcs; Productions animales & zootechnie; productive performance; Restriction fragment length polymorphism; résistance à la diarrhée; Sciences du vivant; Single-nucleotide polymorphism; Swine; Tropical environments; Weaning; Vietnam
• ISSN: 0008-3984; 1918-1825
• DOI: 10.1139/cjas-2019-0084

The alpha (1) fucosyltransferase gene (FUT1) is a candidate gene for controlling the adhesion of Escherichia coli F18 receptor. Indeed, a single-nucleotide polymorphism, c.307G>A, located in the gene is such that pigs with AA genotype are resistant to entero-toxigenic E. coli F18, whereas those with AG and GG genotypes are sensitive. An experiment was carried out in northern Vietnam from March 2016 to May 2017 to determine FUT1 genotype frequencies and the effect of these genotypes on production performance of Yorkshire pigs. A total of 613 animals were genotyped using polymerase chain reaction – restriction fragment length polymorphism method. The body weights at birth, weaning, initial fattening period, and final fattening period were collected from 611, 516, 479, and 418 animals, respectively, whereas backfat thickness, depth of longissimus dorsi, and lean meat percentage were recorded from 328 animals. The frequencies of FUT1 genotypes were found to be in Hardy–Weinberg equilibrium (P = 0.51). Effect of FUT1 genotype was not observed for all production traits (P > 0.05), whereas final body weight and depth of longissimus dorsi were significantly different between females and males (P < 0.05). These results suggest that selection of Yorkshire pigs resistant to entero-toxigenic E. coli F18 could be effective without adversely affecting average daily gain and lean meat.