Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129Xe NMR

Targeted Molecular Imaging of Cancer Cells Using MS2-Based 129Xe NMR

We have synthesized targeted, selective, and highly sensitive 129Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized 129Xe NMR signal co...

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Bibliographic Details
Published in:Bioconjugate chemistry Vol. 27; no. 8; pp. 1796 - 1801
Main Authors: Jeong, Keunhong, Netirojjanakul, Chawita, Munch, Henrik K, Sun, Jinny, Finbloom, Joel A, Wemmer, David E, Pines, Alexander, Francis, Matthew B
Format: Journal Article
Language:English
Published: American Chemical Society 17-08-2016
Online Access:Get full text
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Summary:We have synthesized targeted, selective, and highly sensitive 129Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized 129Xe NMR signal contrast and hyper-CEST 129Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized 129Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.6b00275