Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

Objective. The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant. Methods. The demographic data, radiological and pathological...

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Published in:Journal of Thyroid Research Vol. 2014; no. 2014; pp. 120 - 123
Main Authors: Akyildiz, Mahir, Icoz, Gokhan, Ertan, Yeşim, Makay, Ozer, Erol, Varlık, Yılmaz, Mustafa
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Limiteds 01-01-2014
Hindawi Publishing Corporation
John Wiley & Sons, Inc
Hindawi Limited
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Summary:Objective. The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant. Methods. The demographic data, radiological and pathological data, and prognostic data of 5 patients who underwent surgery for thyroid cancer and were diagnosed with papillary cancer macrofollicular variant pathologically were retrospectively analyzed. Results. The mean age of patients whose mean follow-up period was determined as 7.2 years was 41, and the male/female ratio was 4/1. All patients underwent total thyroidectomy. The pathology report of 2 patients (40%) revealed macrofollicular variant of papillary microcancer, and 3 patients papillary cancer macrofollicular variant. Central dissection was performed in one patient (20%) due to macroscopic pathologic lymph node and 4 metastatic lymph nodes were reported. Also, locoregional recurrence was present in 3 out of 5 patients (60%). Conclusions. Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required.
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Academic Editor: Giovanni Tallini
ISSN:2042-0072
2090-8067
2042-0072
DOI:10.1155/2014/818134