Sex/Gender Differences in Metabolism and Behavior: Influence of Sex Chromosomes and Hormones

• Published in: International Journal of Endocrinology Vol. 2015; pp. 401 - 402-044
• Main Authors: Shi, Haifei, Brown, Lynda M., Rahimian, Roshanak
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi Limiteds 01-01-2015; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Behavior; Endocrinology; Females; Gender differences; Hormones; Hormones, Sex; Influence; Males; Mental disorders; Metabolic disorders; Physiological aspects; Physiology; Reproductive system; Researchers; Sex chromosomes; Sexes; Womens health; United States
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2015/245949

The National Institutes of Health (NIH) in the United States has been directing basic and clinical scientists to consider potential sex differences and perform their studies using cells and tissues derived from both males and females and using both male and female subjects since 2014. A better understanding of the mechanisms underlying the sex-based differences in behavior/metabolism and of the influences of sex chromosomes and hormones is expected to lead to novel therapeutic strategies that would benefit patients of both sexes and enhance the concept of individualized medicine. [...]adequate representation of both sexes in the basic and translational preclinical studies should be provided, as emphasized by the NIH recent requirement intended to minimize sex biases in preclinical research. The goal of this special issue is to stimulate the continuing efforts to demonstrate the breadth of the behavioral, physiological, cellular, and molecular processes beyond the reproductive system which exhibit sex-based differences under physiological and pathological conditions, with a particular concentration on sex chromosomes and hormones.