Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis
IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an...
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| Published in: | Mediators of Inflammation Vol. 2015; no. 2015; pp. 1006 - 1014-493 |
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| Format: | Journal Article |
| Language: | English |
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Cairo, Egypt
Hindawi Limiteds
01-01-2015
Hindawi Publishing Corporation John Wiley & Sons, Inc Hindawi Limited |
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| Abstract | IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status. |
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| AbstractList | IL‐1 β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane‐bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor‐positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL‐1 β membrane‐bound receptors (IL‐1R1 and IL‐1R2) in terms of the percentage of receptor‐positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL‐1 β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane‐bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status. IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status. IL-1 β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and membrane-bound receptors, respectively. The effectiveness of the cytokine depends not only on the percentage of receptor-positive cells in an immunocompetent subset but also on the density of receptor expression. The objective of this study was to investigate the expression of IL-1 β membrane-bound receptors (IL-1R1 and IL-1R2) in terms of the percentage of receptor-positive cells and the number of receptors per cell in different subsets of immune cells in RA patients before and after a course of basic (excluding anticytokine) therapy and in healthy individuals. The resulting data indicate differences in the expression of IL-1 β receptors among T cells, B cells, and monocytes in healthy volunteers and in rheumatoid arthritis patients. The importance of determining both the relative percentage of cells expressing receptors to immunomodulatory cytokines and the number of membrane-bound receptors per cell is highlighted by evidence of unidirectional or multidirectional changing of these parameters according to cell subset and health status. |
| Audience | Academic |
| Author | Nadezhda S. Shkaruba Oksana A. Chumasova Alina A. Alshevskaya Julia A. Lopatnikova Aleksey E. Sizikov Vladimir A. Kozlov Sergey V. Sennikov Aleksander V. Karaulov |
| AuthorAffiliation | 1 Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, Russia 2 I.M. Sechenov First Moscow State Medical University of the Ministry of Health, Bolshaya Pirogovskaya Street 2-4, Moscow 119991, Russia |
| AuthorAffiliation_xml | – name: 1 Federal State Budgetary Scientific Institution “Research Institute of Fundamental and Clinical Immunology”, Yadrintsevskaya Street 14, Novosibirsk 630099, Russia – name: 2 I.M. Sechenov First Moscow State Medical University of the Ministry of Health, Bolshaya Pirogovskaya Street 2-4, Moscow 119991, Russia |
| Author_xml | – sequence: 1 fullname: Sennikov, Sergey V. – sequence: 2 fullname: Karaulov, Aleksander V. – sequence: 3 fullname: Sizikov, Aleksey E. – sequence: 4 fullname: Chumasova, Oksana A. – sequence: 5 fullname: Shkaruba, Nadezhda S. – sequence: 6 fullname: Anatolievna, Lopatnikova Julia – sequence: 7 fullname: Alshevskaya, Alina A. – sequence: 8 fullname: Kozlov, Vladimir A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26448682$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.4049/jimmunol.153.10.4766 10.4049/jimmunol.171.12.6814 10.1111/j.1600-065x.2008.00624.x 10.1152/ajpcell.2001.280.4.C943 10.4049/jimmunol.158.8.3861 10.1038/nrrheum.2010.4 10.1016/j.smim.2013.10.008 10.1006/clin.1994.1100 10.1007/s10616-013-9546-6 10.1126/science.8332913 10.1172/jci26631 10.1093/rheumatology/keu351 10.1016/S0021-9258(19)49611-7 10.1016/s1471-4906(01)01941-x 10.1007/bf03044757 10.1111/j.1600-065x.2008.00701.x 10.1146/annurev.immunol.14.1.397 10.1073/pnas.92.5.1714 10.1086/315315 10.1084/jem.183.4.1841 10.1155/2014/681678 10.1038/nri2094 10.1371/journal.pone.0005293 10.1097/MED.0000000000000103 10.2174/1381612820666140825122247 10.1186/ar4130 10.1128/mcb.01808-08 10.1111/jcmm.12200 10.2332/allergolint.10-RAI-0190 10.1002/eji.200737395 |
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| Copyright | Copyright © 2015 Alina A. Alshevskaya et al. COPYRIGHT 2015 John Wiley & Sons, Inc. Copyright © 2015 Alina A. Alshevskaya et al. 2015 |
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| Snippet | IL-1β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and... IL‐1 β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and... IL-1 β is involved in the induction and maintenance of chronic inflammation in rheumatoid arthritis (RA). Its activity is regulated and induced by soluble and... |
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| SubjectTerms | Adolescent Adult Aged Arthritis, Rheumatoid - metabolism B-Lymphocytes - metabolism Female Flow Cytometry Gene expression Genetic aspects Health aspects Humans Interleukin-1beta - metabolism Interleukins Male Middle Aged Monocytes - metabolism Observations Receptors, Interleukin-1 - metabolism Rheumatoid arthritis T-Lymphocytes - metabolism Young Adult |
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| Title | Differences of IL-1β Receptors Expression by Immunocompetent Cells Subsets in Rheumatoid Arthritis |
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