Use of Preclinical Data for Selection of a Phase II/III Dose for Evernimicin and Identification of a Preclinical MIC Breakpoint

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 45; no. 1; pp. 13 - 22
Main Authors:	DRUSANO, G. L, PRESTON, S. L, HARDALO, C, HARE, R, BANFIELD, C, ANDES, D, VESGA, O, CRAIG, W. A
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-01-2001
Subjects:	Aminoglycosides Animals Anti-Bacterial Agents Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Area Under Curve Bacterial Infections - chemically induced Bacterial Infections - microbiology Biological and medical sciences Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Enterococcus faecalis Enterococcus faecium Evernimicin Experimental Therapeutics Gram-Positive Bacteria - drug effects Medical sciences Methicillin Resistance Mice Microbial Sensitivity Tests Monte Carlo Method Oligosaccharides - pharmacology Pharmacology. Drug treatments Protein Binding Staphylococcus aureus Staphylococcus aureus - drug effects Streptococcus pneumoniae Human Monte Carlo method Intravenous administration Oligosaccharide Rodentia Preclinical trial Normal In vitro Biological activity In vivo Vertebrata Antibiotic Mammalia Simulation Mouse Animal Minimum inhibitory concentration Antiinfectious Antibacterial agent Mathematical model Pharmacokinetics
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 Corresponding author. Mailing address: Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Albany Medical College, 47 New Scotland Ave., Albany, NY 12208. Phone: (518) 262-6330. Fax: (518) 262-6333. E-mail: GLDRUSANO@AOL.COM.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.45.1.13-22.2001