Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan

We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not d...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 59; no. 2; pp. 1356 - 1359
Main Authors:	Kayama, Shizuo, Shigemoto, Norifumi, Kuwahara, Ryuichi, Oshima, Kenshiro, Hirakawa, Hideki, Hisatsune, Junzo, Jové, Thomas, Nishio, Hisaaki, Yamasaki, Katsutoshi, Wada, Yasunao, Ueshimo, Takeshi, Miura, Tetsuya, Sueda, Taijiro, Onodera, Makoto, Yokozaki, Michiya, Hattori, Masahira, Ohge, Hiroki, Sugai, Motoyuki
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-02-2015
Subjects:	beta-Lactamases beta-Lactamases - metabolism Enterobacteriaceae Enterobacteriaceae - drug effects Enterobacteriaceae - enzymology Epidemiology and Surveillance Imipenem - pharmacology Japan Klebsiella pneumoniae Microbial Sensitivity Tests Molecular Sequence Data Plasmids - genetics Japan
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Summary:	We have determined the DNA sequence of Klebsiella pneumoniae multidrug resistance plasmid pKPI-6, which is a self-transmissible IncN-type plasmid. pKPI-6 harboring blaIMP-6 and blaCTX-M-2 confers a stealth-type carbapenem resistance phenotype on members of the family Enterobacteriaceae that is not detectable with imipenem. pKPI-6 is already epidemic in Japan, favoring the dissemination of IMP-6 and CTX-M-2 in members of the family Enterobacteriaceae.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 S.K. and N.S. contributed equally to this study. Citation Kayama S, Shigemoto N, Kuwahara R, Oshima K, Hirakawa H, Hisatsune J, Jové T, Nishio H, Yamasaki K, Wada Y, Ueshimo T, Miura T, Sueda T, Onodera M, Yokozaki M, Hattori M, Ohge H, Sugai M. 2015. Complete nucleotide sequence of the IncN plasmid encoding IMP-6 and CTX-M-2 from emerging carbapenem-resistant Enterobacteriaceae in Japan. Antimicrob Agents Chemother 59:1356–1359. doi:10.1128/AAC.04759-14.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.04759-14