Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA

• Published in: Antimicrobial Agents and Chemotherapy Vol. 50; no. 4; pp. 1489 - 1496
• Main Authors: HOBBIE, Sven N, PFISTER, Peter, BRUELL, Christian, SANDER, Peter, FRANCOIS, Boris, WESTHOF, Eric, BÖTTGER, Erik C
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-04-2006
• Subjects: Anti-Bacterial Agents; Anti-Bacterial Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Binding Sites; Biochemistry, Molecular Biology; Biological and medical sciences; Life Sciences; Mechanisms of Action: Physiological Effects; Medical sciences; Mutagenesis, Site-Directed; Mycobacterium smegmatis; Neomycin; Neomycin - chemistry; Neomycin - metabolism; Pharmacology. Drug treatments; Ribosomes; Ribosomes - chemistry; Ribosomes - metabolism; RNA, Ribosomal, 16S; RNA, Ribosomal, 16S - chemistry; Structure-Activity Relationship; Antibiotic; Ribosome; Aminoglycoside; Neomycin; 16S-RNA; Mutation; Antibacterial agent
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.50.4.1489-1496.2006

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