A Family of Insertion Mutations between Codons 67 and 70 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Multinucleoside Analog Resistance

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 43; no. 8; pp. 1961 - 1967
Main Authors:	LARDER, B. A, BLOOR, S, STUART, D. I, PAUWELS, R, KEMP, S. D, HERTOGS, K, DESMET, R. L, MILLER, V, STURMER, M, STASZEWSKI, S, REN, J, STAMMERS, D. K
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-08-1999
Subjects:	Anti-HIV Agents Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Binding Sites Biological and medical sciences Codon Dideoxynucleosides Dideoxynucleosides - pharmacology DNA Transposable Elements Drug Resistance, Multiple Drug Resistance, Multiple - genetics Genotype HIV Infections - blood HIV Infections - drug therapy HIV Reverse Transcriptase HIV Reverse Transcriptase - genetics HIV-1 HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Humans Medical sciences Microbial Sensitivity Tests Multigene Family Mutagenesis, Insertional Pharmacology. Drug treatments Phenotype Protein Conformation Human RNA-directed DNA polymerase HIV-1 virus Enzyme Transferases Active site Site directed mutagenesis Retroviridae Insertion Molecular interaction Lentivirus Virus Resistance Nucleotidyltransferases Biological fixation Dideoxynucleoside Antiviral Nucleoside Human immunodeficiency virus Mutation Pyrimidine nucleoside Zidovudine
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address: Virco UK, 184 Cambridge Science Park, Milton Rd., Cambridge, CB4 4GH, United Kingdom. Phone: 44 1 223 728 828. Fax: 44 1 223 728 801. E-mail: brendan.larder@virco.co.uk.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/aac.43.8.1961