The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease
This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specif...
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| Published in: | Mediators of Inflammation Vol. 2008; no. 2008; pp. 119 - 124 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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Cairo, Egypt
Hindawi Limiteds
01-01-2008
Hindawi Publishing Corporation Hindawi John Wiley & Sons, Inc |
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| Abstract | This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35, p<.05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset. |
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| AbstractList | This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35, p<.05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset. This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group comprises 27 patients at the mean age of 12.30 years (+/-SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r = -0.35, p < .05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset. This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD ( r = −0.35, p < .05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset. This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group comprises 27 patients at the mean age of 12.30 years ( ± SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD ( r = ‐ 0.35 , p < .05 ) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset. |
| Audience | Academic |
| Author | Siekiera, Urszula Deja, Grazyna Myrda, Anna Jarosz-Chobot, Przemyslawa |
| AuthorAffiliation | 3 Blood Center, 40-074 Katowice, Poland 1 Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, 40-752 Katowice, Poland 2 Schwarzwald-Baar Klinikum, 78011 Villingen-Schwenningen, Germany |
| AuthorAffiliation_xml | – name: 3 Blood Center, 40-074 Katowice, Poland – name: 1 Department of Pediatrics, Endocrinology and Diabetes, Medical University of Silesia, 40-752 Katowice, Poland – name: 2 Schwarzwald-Baar Klinikum, 78011 Villingen-Schwenningen, Germany |
| Author_xml | – sequence: 1 fullname: Siekiera, Urszula – sequence: 2 fullname: Jarosz-Chobot, Przemyslawa – sequence: 3 fullname: Myrda, Anna – sequence: 4 fullname: Deja, Grazyna |
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| CitedBy_id | crossref_primary_10_23950_1812_2892_JCMK_00755 crossref_primary_10_4239_wjd_v11_i11_527 crossref_primary_10_1016_j_pcd_2021_08_011 crossref_primary_10_1155_2020_7869350 |
| Cites_doi | 10.1210/jc.84.5.1534 10.1097/00005176-200307000-00011 10.1093/nar/16.3.1215 10.1542/peds.109.5.833 10.1007/s00125-002-0781-1 10.1136/adc.2003.029603 10.1002/(SICI)1096-9136(199605)13:5<464::AID-DIA101>3.0.CO;2-R 10.1111/j.1651-2227.2004.tb02987.x 10.1515/jpem-2006-190409 10.1006/jaut.1999.0303 10.1111/j.1651-2227.1996.tb14253.x 10.2337/diacare.28.9.2170 10.1155/MI/2006/19724 10.1097/00005176-200501000-00001 10.1007/s00592-007-0017-4 10.1067/S0022-3476(03)00282-8 10.2337/dc06-0794 10.2337/diacare.28.4.806 10.2337/dc06-0990 10.2337/diacare.24.1.27 10.2337/diacare.28.4.850 10.1542/peds.113.5.e418 10.1046/j.1464-5491.2000.00291.x 10.1002/ajmg.10343 |
| ContentType | Journal Article |
| Copyright | Copyright © 2008 2009 INIST-CNRS COPYRIGHT 2008 John Wiley & Sons, Inc. Copyright © 2008 Grazyna Deja et al. 2008 |
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| Issue | 2008 |
| Keywords | Endocrinopathy Human Immunopathology Prevalence Intestinal malabsorption Type 1 diabetes Autoimmune disease Digestive diseases Intestinal disease Coeliac disease Child Epidemiology |
| Language | English |
| License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0 |
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| References_xml | – volume: 1 start-page: 178 year: 1996 end-page: 184 ident: 9 article-title: Coincidence of type 1 diabetes mellitus and coeliac disease – volume: 115 start-page: 48 issue: 1 year: 2002 end-page: 54 ident: 30 article-title: Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes – volume: 24 start-page: 27 issue: 1 year: 2001 end-page: 32 ident: 12 article-title: Comparative analysis of organ-specific autoantibodies and celiac disease—associated antibodies in type 1 diabetic patients, their first-degree relatives, and healthy control subjects – volume: 28 start-page: 806 issue: 4 year: 2005 end-page: 809 ident: 28 article-title: Use of HLA typing in diagnosing celiac disease in patients with type 1 diabetes – volume: 45 start-page: 37 issue: 1 year: 2008 end-page: 40 ident: 23 article-title: An analysis of the prevalence of thyroid autoantibodies: thyroid peroxidase antibodies (ATA) and thyroglobulin antibodies (ATG) in children with newly diagnosed diabetes mellitus type 1 during 2000–2004 in the Upper Silesia region, Poland – volume: 13 start-page: 143 issue: 1 year: 1999 end-page: 148 ident: 25 article-title: One third of HLA DQ2 homozygous patients with type 1 diabetes express celiac disease-associated transglutaminase autoantibodies – volume: 7 start-page: 104 issue: 2 year: 2000 end-page: 107 ident: 21 article-title: Thyroid disorders in children suffering from poorly controlled type 1 diabetes mellitus – volume: 29 start-page: 99 issue: 2 year: 2007 end-page: 104 ident: 19 article-title: Early diagnosis and treatment of celiac disease in type 1 diabetes. 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| Snippet | This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group... This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM). The study group... |
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| SubjectTerms | Adolescent Age Factors Autoantibodies - immunology Biological and medical sciences Celiac Disease - complications Celiac Disease - epidemiology Celiac Disease - immunology Child Comorbidity Diabetes Mellitus, Type 1 - complications Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Male Medical sciences Other diseases. Semiology Poland - epidemiology Prevalence Retrospective Studies Risk Factors Sex Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Thyroiditis - complications Thyroiditis - epidemiology Thyroiditis - immunology |
| Title | The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease |
| URI | https://www.airitilibrary.com/Article/Detail/P20160527003-200812-201702140004-201702140004-119-124 https://search.emarefa.net/detail/BIM-988144 https://dx.doi.org/10.1155/2008/285989 https://www.ncbi.nlm.nih.gov/pubmed/18437226 https://search.proquest.com/docview/69143917 https://pubmed.ncbi.nlm.nih.gov/PMC2323534 |
| Volume | 2008 |
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