The Assessment of Autoimmunological Status and Prevalence of Different Forms of Celiac Disease among Children with Type 1 Diabetes Mellitus and Celiac Disease

• Published in: Mediators of Inflammation Vol. 2008; no. 2008; pp. 119 - 124
• Main Authors: Siekiera, Urszula, Jarosz-Chobot, Przemyslawa, Myrda, Anna, Deja, Grazyna
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Limiteds 01-01-2008; Hindawi Publishing Corporation; Hindawi; John Wiley & Sons, Inc
• Subjects: Adolescent; Age Factors; Autoantibodies - immunology; Biological and medical sciences; Celiac Disease - complications; Celiac Disease - epidemiology; Celiac Disease - immunology; Child; Comorbidity; Diabetes Mellitus, Type 1 - complications; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Male; Medical sciences; Other diseases. Semiology; Poland - epidemiology; Prevalence; Retrospective Studies; Risk Factors; Sex Factors; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Thyroiditis - complications; Thyroiditis - epidemiology; Thyroiditis - immunology; Poland; Endocrinopathy; Human; Immunopathology; Prevalence; Intestinal malabsorption; Type 1 diabetes; Autoimmune disease; Digestive diseases; Intestinal disease; Coeliac disease; Child; Epidemiology
• ISSN: 0962-9351; 1466-1861
• DOI: 10.1155/2008/285989

This study aims to assess the autoimmunological status and forms of celiac disease (CD) among children with type 1 diabetes mellitus (T1DM) . The study group comprises 27 patients at the mean age of 12.30 years (±SD 3.12). The measurement of the level of diabetes-specific antibodies and organ-specific antibodies was gained at the T1DM-onset and repeated annually. The following risk factors influencing time of CD diagnosis were analyzed: age, sex, T1DM duration, autoantibodies, and HLA-haplotype. The prevalence of antibodies was GADA-74%, IAA-63%, IA2A-67%, ATA-11%, and ATG-4%. The intestinal biopsy revealed in 19% no changes and in 77% stage 3 (Marsh scale). In most cases, no clinical manifestation of CD was observed. The diagnosis of Hashimoto's disease was made twice. The negative correlation between the age at T1DM-onset and the interval between onset of T1DM and CD (r=‐0.35, p<.05) was noted. The high-comorbidity ratio of CD and thyroiditis with T1DM demands regular screening tests especially in the first years after T1DM-onset.