Photochemical Access to Substituted β‑Lactams and β‑Lactones via the Zimmerman–O’Connell–Griffin Rearrangement

A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman–O’Connell–Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent diastereoselectivity...

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Bibliographic Details
Published in:	Organic letters Vol. 25; no. 29; pp. 5520 - 5524
Main Authors:	Runemark, August, Martos, Mario, Nigríni, Martin, Amombo Noa, Francoise M., Öhrström, Lars, Sundén, Henrik
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 28-07-2023
Subjects:	Chemical Sciences Chemistry Kemi laser flash-photolysis Letter state transformations
Online Access:	Get full text
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Summary:	A photomediated protocol giving facile access to substituted β-lactam and β-lactones is presented. The method realizes, for the first time, the use of the Zimmerman–O’Connell–Griffin (ZOG) rearrangement in [2 + 2] cycloaddition. Products are obtained in high yield with excellent diastereoselectivity under visible light irradiation and under mild reaction conditions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1523-7060 1523-7052 1523-7052
DOI:	10.1021/acs.orglett.3c01990