Nerve Growth Factor and Pain Mechanisms

Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology....

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Bibliographic Details
Published in:	Annual review of neuroscience Vol. 40; no. 1; pp. 307 - 325
Main Authors:	Denk, Franziska, Bennett, David L, McMahon, Stephen B
Format:	Journal Article
Language:	English
Published:	United States Annual Reviews 25-07-2017 Annual Reviews, Inc
Subjects:	Analgesics Animals Antagonism chronic pain Chronic Pain - metabolism Humans Nerve growth factor Nerve Growth Factor - metabolism Osteoarthritis p75 Pain Pain - metabolism Peptides Receptor, Nerve Growth Factor - metabolism Receptor, trkA - metabolism Side effects trkA chronic pain trkA nerve growth factor p75
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Summary:	Nerve growth factor (NGF) antagonism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including osteoarthritis and lower back pain. This review summarizes the historical research, both fundamental and clinical, that led to our current understanding of NGF biology. We also discuss the surprising number of questions that remain about NGF expression patterns and NGF's various functions and interaction partners in relation to persistent pain and the potential side effects of anti-NGF therapy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0147-006X 1545-4126
DOI:	10.1146/annurev-neuro-072116-031121