Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication

• Published in: Antimicrobial Agents and Chemotherapy Vol. 54; no. 5; pp. 2017 - 2022
• Main Authors: KARPENKO, Inna, DEEV, Sergey, KOCHETKOV, Sergey, CHUPAKHIN, Oleg, KUKHANOVA, Marina, KISELEV, Oleg, CHARUSHIN, Valerey, RUSINOV, Vladimir, ULOMSKY, Eugeney, DEEVA, Ella, YANVAREV, Dmitry, IVANOV, Alexander, SMIRNOVA, Olga
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-05-2010; American Society for Microbiology (ASM)
• Subjects: Animals; Antiviral Agents; Antiviral Agents - chemistry; Antiviral Agents - pharmacokinetics; Azoles; Azoles - chemistry; Azoles - pharmacokinetics; Disease Models, Animal; Dogs; Drug Design; Hepatocytes - cytology; Hepatocytes - virology; Humans; Influenza A virus; Influenza A virus - drug effects; Influenza A virus - growth & development; Influenza B virus; Influenza B virus - drug effects; Influenza B virus - growth & development; Injections, Intravenous; Kidney - cytology; Mice; Mice, Inbred CBA; Orthomyxoviridae Infections; Orthomyxoviridae Infections - drug therapy; Pharmacology; Rabbits; Stomach; Triazines; Triazines - chemistry; Triazines - pharmacokinetics; Virus Replication; Virus Replication - drug effects
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.01186-09

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