Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 45; no. 11; pp. 3162 - 3170
Main Authors:	CRUZ, M. Cristina, GOLDSTEIN, Alan L, BLANKENSHIP, Jill, DEL POETA, Maurizio, PERFECT, John R, MCCUSKER, John H, BENNANI, Youssef L, CARDENAS, Maria E, HEITMAN, Joseph
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-11-2001
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal Agents Antifungal Agents - pharmacology Biological and medical sciences Candida albicans Candida albicans - drug effects Candida albicans - genetics Cryptococcus neoformans Cryptococcus neoformans - drug effects Cryptococcus neoformans - growth & development Culture Media DNA Primers Drug Resistance FKBP12 protein Fungal Proteins Fungal Proteins - drug effects Fungal Proteins - genetics Immunosuppressive Agents Immunosuppressive Agents - pharmacology Mechanisms of Action: Physiological Effects Medical sciences Mutagenesis Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases Phosphotransferases (Alcohol Group Acceptor) Phosphotransferases (Alcohol Group Acceptor) - drug effects Phosphotransferases (Alcohol Group Acceptor) - genetics Recombination, Genetic Reverse Transcriptase Polymerase Chain Reaction Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae Proteins Sirolimus Sirolimus - analogs & derivatives Sirolimus - pharmacology Tacrolimus Binding Protein 1A Tacrolimus Binding Protein 1A - drug effects Tor kinase Candida albicans Yeast Cryptococcus neoformans Sirolimus Toxicity Macrolide Biological activity Fungi Resistance Antifungal agent Mutagenesis Analog Fungi Imperfecti Immunosuppressive agent Mechanism of action Thallophyta
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address: Box 3546, 322 CARL Bldg., Research Dr., Duke University Medical Center, Durham, NC 27710. Phone: (919) 684-2824. Fax: (919) 684-5458. E-mail: heitm001@duke.edu.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.45.11.3162-3170.2001