Population Pharmacokinetics and Pharmacodynamics of Continuous versus Short-Term Infusion of Imipenem-Cilastatin in Critically Ill Patients in a Randomized, Controlled Trial

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 51; no. 9; pp. 3304 - 3310
Main Authors:	SAKKA, Samir G, GLAUNER, Anna K, BULITTA, Jürgen B, KINZIG-SCHIPPERS, Martina, PFISTER, Wolfgang, DRUSANO, George L, SÖRGEL, Fritz
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-09-2007
Subjects:	Adult Aged Aged, 80 and over Analysis of Variance Anti-Bacterial Agents Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Chromatography, High Pressure Liquid Cilastatin Cilastatin - administration & dosage Cilastatin - pharmacokinetics Cilastatin - therapeutic use Clinical Therapeutics Critical Illness Cross Infection Cross Infection - drug therapy Cross Infection - microbiology Drug Combinations Female Humans Imipenem Imipenem - administration & dosage Imipenem - pharmacokinetics Imipenem - therapeutic use Infusions, Intravenous Logistic Models Male Medical sciences Middle Aged Monte Carlo Method Pharmacology. Drug treatments Protease Inhibitors Protease Inhibitors - administration & dosage Protease Inhibitors - pharmacokinetics Protease Inhibitors - therapeutic use Tandem Mass Spectrometry Treatment Outcome Short term Human Pharmacokinetic pharmacodynamic relationship Population pharmacokinetics Enzyme Critically ill β-Lactams Cilastatin Enzyme inhibitor Continuous process Peptidases Carbapenem derivatives Antibiotic Perfusion Randomised controlled trial Hydrolases Antibacterial agent Comparative study Imipenem
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: State University of New York at Buffalo, Buffalo, NY 14260. Present address: Department of Anesthesiology and Intensive Care Medicine, Medical Center Cologne-Merheim, University Witten/Herdecke, Cologne, Germany. Corresponding author. Mailing address: Institute for Biomedical and Pharmaceutical Research, Paul-Ehrlich-Str. 19, D-90562 Nürnberg-Heroldsberg, Germany. Phone: 49-911-518290. Fax: 49-911-5182920. E-mail: ibmp@osn.de
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.01318-06