Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis
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| Published in: | Antimicrobial Agents and Chemotherapy Vol. 48; no. 8; pp. 3006 - 3009 |
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| AbstractList | Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis, INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used 15N-labeled INH together with electron paramagnetic resonance spin trapping techniques to demonstrate that nitric oxide (NO˙) is generated from oxidation at the hydrazide nitrogens during the activation of INH by M. tuberculosis KatG. We also observed that a specific scavenger of NO˙ provided protection against the antimycobacterial activity of INH in bacterial culture. No significant increases in mycobacterial protein nitration were detected, suggesting that NO˙ and not peroxynitrite, a nitrating metabolite of NO·, is involved in antimycobacterial action. In conclusion, INH-derived NO· has biological activity, which directly contributes to the antimycobacterial action of INH. Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis , INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used 15 N-labeled INH together with electron paramagnetic resonance spin trapping techniques to demonstrate that nitric oxide (NO˙) is generated from oxidation at the hydrazide nitrogens during the activation of INH by M. tuberculosis KatG. We also observed that a specific scavenger of NO˙ provided protection against the antimycobacterial activity of INH in bacterial culture. No significant increases in mycobacterial protein nitration were detected, suggesting that NO˙ and not peroxynitrite, a nitrating metabolite of NO · , is involved in antimycobacterial action. In conclusion, INH-derived NO · has biological activity, which directly contributes to the antimycobacterial action of INH. Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis, INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used 15N-labeled INH together with electron paramagnetic resonance spin trapping techniques to demonstrate that nitric oxide (NO*) is generated from oxidation at the hydrazide nitrogens during the activation of INH by M. tuberculosis KatG. We also observed that a specific scavenger of NO* provided protection against the antimycobacterial activity of INH in bacterial culture. No significant increases in mycobacterial protein nitration were detected, suggesting that NOdot; and not peroxynitrite, a nitrating metabolite of NO*, is involved in antimycobacterial action. In conclusion, INH-derived NO* has biological activity, which directly contributes to the antimycobacterial action of INH. Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis , INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used 15 N-labeled INH together with electron paramagnetic resonance spin trapping techniques to demonstrate that nitric oxide (NȮ) is generated from oxidation at the hydrazide nitrogens during the activation of INH by M. tuberculosis KatG. We also observed that a specific scavenger of NȮ provided protection against the antimycobacterial activity of INH in bacterial culture. No significant increases in mycobacterial protein nitration were detected, suggesting that NȮ and not peroxynitrite, a nitrating metabolite of NO · , is involved in antimycobacterial action. In conclusion, INH-derived NO · has biological activity, which directly contributes to the antimycobacterial action of INH. Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis, INH requires activation by the catalase-peroxidase KatG, converting INH from its prodrug form into a range of bactericidal reactive species. Here we used super(15)N-labeled INH together with electron paramagnetic resonance spin trapping techniques to demonstrate that nitric oxide (NO super(.)) is generated from oxidation at the hydrazide nitrogens during the activation of INH by M. tuberculosis KatG. We also observed that a specific scavenger of NO super(.) provided protection against the antimycobacterial activity of INH in bacterial culture. No significant increases in mycobacterial protein nitration were detected, suggesting that NO super(.) and not peroxynitrite, a nitrating metabolite of NO super(.), is involved in antimycobacterial action. In conclusion, INH-derived NO super(.) has biological activity, which directly contributes to the antimycobacterial action of INH. Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC |
| Author | Vojo Deretic Frank Rusnak Sharon Master Graham S. Timmins |
| AuthorAffiliation | College of Pharmacy, Toxicology Program, 1 Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, 2 Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905 3 |
| AuthorAffiliation_xml | – name: College of Pharmacy, Toxicology Program, 1 Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, 2 Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905 3 |
| Author_xml | – sequence: 1 givenname: Graham S surname: TIMMINS fullname: TIMMINS, Graham S organization: College of Pharmacy, Toxicology Program, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States – sequence: 2 givenname: Sharon surname: MASTER fullname: MASTER, Sharon organization: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States – sequence: 3 givenname: Frank surname: RUSNAK fullname: RUSNAK, Frank organization: Department of Biochemistry and Molecular Biology and Section of Hematology Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905, United States – sequence: 4 givenname: Vojo surname: DERETIC fullname: DERETIC, Vojo organization: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, United States |
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| Cites_doi | 10.1111/j.1600-0773.1984.tb01916.x 10.1038/358591a0 10.1128/IAI.69.12.7711-7717.2001 10.1126/science.8284673 10.1016/S0021-9258(18)47160-8 10.1016/0003-9861(84)90147-4 10.1021/ja00095a063 10.1099/00221287-148-10-3139 10.1128/AAC.27.3.408 10.1016/0006-2952(94)90502-9 10.1016/S1286-4579(00)00359-2 10.1006/bbrc.1999.0358 10.1021/ja012271v 10.1124/mol.52.6.1081 10.1021/bi002614m 10.1086/514096 10.1038/nbt1196-1557 10.1021/ja9918674 10.1073/pnas.93.23.13212 10.1073/pnas.84.10.3189 10.1128/AAC.46.9.2765-2771.2002 10.1016/0925-4439(95)00061-8 10.1046/j.1365-2958.2002.03162.x 10.1084/jem.175.4.1111 10.1021/jo01119a010 10.1126/science.279.5347.98 10.1021/tx034188m 10.1054/tuld.1998.0203 10.1128/AAC.47.7.2299-2302.2003 10.1046/j.1365-2958.2000.02145.x 10.1126/science.280.5369.1607 |
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| Keywords | Mycobacterium tuberculosis Mycobacteriales Nitric oxide Mycobacteriaceae Bacteria Actinomycetes Activation Antituberculous agent Antibacterial agent Isoniazid |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Deceased. Corresponding author. Mailing address: College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131. Phone: (505) 272-4103. Fax: (505) 272-6749. E-mail: gtimmins@salud.unm.edu. |
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| References | e_1_3_2_27_2 e_1_3_2_28_2 e_1_3_2_21_2 e_1_3_2_22_2 e_1_3_2_23_2 e_1_3_2_25_2 (e_1_3_2_19_2) 1984; 229 e_1_3_2_9_2 (e_1_3_2_10_2) 1997; 2 e_1_3_2_15_2 e_1_3_2_38_2 e_1_3_2_8_2 e_1_3_2_16_2 e_1_3_2_37_2 (e_1_3_2_3_2) 1994; 375 e_1_3_2_7_2 e_1_3_2_17_2 e_1_3_2_6_2 (e_1_3_2_26_2) 2004; 17 (e_1_3_2_24_2) 1984; 54 e_1_3_2_30_2 e_1_3_2_32_2 e_1_3_2_31_2 e_1_3_2_5_2 e_1_3_2_11_2 e_1_3_2_34_2 e_1_3_2_4_2 e_1_3_2_12_2 e_1_3_2_33_2 e_1_3_2_13_2 e_1_3_2_36_2 e_1_3_2_2_2 e_1_3_2_14_2 (e_1_3_2_35_2) 1969; 99 (e_1_3_2_29_2) 1999; 121 (e_1_3_2_20_2) 1997; 283 (e_1_3_2_18_2) 1998; 217 |
| References_xml | – volume: 54 start-page: 189 year: 1984 ident: e_1_3_2_24_2 publication-title: Acta Pharmacol. Toxicol. doi: 10.1111/j.1600-0773.1984.tb01916.x – ident: e_1_3_2_38_2 doi: 10.1038/358591a0 – volume: 2 start-page: 2167 year: 1997 ident: e_1_3_2_10_2 publication-title: J. Chem. Soc. Perkin Trans. I – ident: e_1_3_2_23_2 doi: 10.1128/IAI.69.12.7711-7717.2001 – ident: e_1_3_2_2_2 doi: 10.1126/science.8284673 – ident: e_1_3_2_22_2 doi: 10.1016/S0021-9258(18)47160-8 – volume: 229 start-page: 220 year: 1984 ident: e_1_3_2_19_2 publication-title: Arch. Biochem. Biophys. doi: 10.1016/0003-9861(84)90147-4 – volume: 99 start-page: 729 year: 1969 ident: e_1_3_2_35_2 publication-title: Am. Rev. Respir. Dis. – ident: e_1_3_2_13_2 doi: 10.1021/ja00095a063 – ident: e_1_3_2_16_2 doi: 10.1099/00221287-148-10-3139 – ident: e_1_3_2_25_2 doi: 10.1128/AAC.27.3.408 – ident: e_1_3_2_34_2 – volume: 217 start-page: 209 year: 1998 ident: e_1_3_2_18_2 publication-title: Novartis Found. Symp. – ident: e_1_3_2_30_2 doi: 10.1016/0006-2952(94)90502-9 – ident: e_1_3_2_27_2 doi: 10.1016/S1286-4579(00)00359-2 – ident: e_1_3_2_31_2 doi: 10.1006/bbrc.1999.0358 – ident: e_1_3_2_11_2 doi: 10.1021/ja012271v – ident: e_1_3_2_12_2 doi: 10.1124/mol.52.6.1081 – ident: e_1_3_2_32_2 doi: 10.1021/bi002614m – ident: e_1_3_2_33_2 doi: 10.1086/514096 – ident: e_1_3_2_8_2 doi: 10.1038/nbt1196-1557 – volume: 121 start-page: 10962 year: 1999 ident: e_1_3_2_29_2 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja9918674 – ident: e_1_3_2_37_2 doi: 10.1073/pnas.93.23.13212 – ident: e_1_3_2_5_2 doi: 10.1073/pnas.84.10.3189 – ident: e_1_3_2_4_2 doi: 10.1128/AAC.46.9.2765-2771.2002 – ident: e_1_3_2_14_2 doi: 10.1016/0925-4439(95)00061-8 – ident: e_1_3_2_15_2 doi: 10.1046/j.1365-2958.2002.03162.x – ident: e_1_3_2_6_2 doi: 10.1084/jem.175.4.1111 – ident: e_1_3_2_9_2 doi: 10.1021/jo01119a010 – ident: e_1_3_2_21_2 doi: 10.1126/science.279.5347.98 – volume: 17 start-page: 234 year: 2004 ident: e_1_3_2_26_2 publication-title: Chem. Res. Toxicol. doi: 10.1021/tx034188m – ident: e_1_3_2_36_2 doi: 10.1054/tuld.1998.0203 – volume: 375 start-page: 81 year: 1994 ident: e_1_3_2_3_2 publication-title: Biol. Chem. Hoppe-Seyler – ident: e_1_3_2_7_2 doi: 10.1128/AAC.47.7.2299-2302.2003 – ident: e_1_3_2_28_2 doi: 10.1046/j.1365-2958.2000.02145.x – ident: e_1_3_2_17_2 doi: 10.1126/science.280.5369.1607 – volume: 283 start-page: 138 year: 1997 ident: e_1_3_2_20_2 publication-title: J. Pharmacol. Exp. Ther. |
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Reddit... Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis, INH requires activation by the... Isonicotinic acid hydrazide (INH) is a frontline antituberculosis agent. Once taken up by Mycobacterium tuberculosis , INH requires activation by the... |
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| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Bacterial Proteins Biological and medical sciences Biotransformation Catalase - metabolism Free Radical Scavengers - pharmacology Isoniazid Isoniazid - metabolism Isoniazid - pharmacology Mechanisms of Action: Physiological Effects Medical sciences Mycobacterium bovis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Nitric Oxide Nitric Oxide - metabolism Oxidoreductases Oxidoreductases - genetics Oxidoreductases - metabolism Oxidoreductases - physiology Peroxidase - metabolism Peroxynitrous Acid - metabolism Pharmacology. Drug treatments Prodrugs - metabolism Prodrugs - pharmacology Spin Trapping Tyrosine Tyrosine - analogs & derivatives Tyrosine - metabolism |
| Title | Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis |
| URI | http://aac.asm.org/content/48/8/3006.abstract https://www.ncbi.nlm.nih.gov/pubmed/15273113 https://journals.asm.org/doi/10.1128/AAC.48.8.3006-3009.2004 https://search.proquest.com/docview/17720943 https://pubmed.ncbi.nlm.nih.gov/PMC478481 |
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