Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 48; no. 8; pp. 3006 - 3009
Main Authors:	TIMMINS, Graham S, MASTER, Sharon, RUSNAK, Frank, DERETIC, Vojo
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-08-2004
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents Antitubercular Agents - metabolism Antitubercular Agents - pharmacology Bacterial Proteins Biological and medical sciences Biotransformation Catalase - metabolism Free Radical Scavengers - pharmacology Isoniazid Isoniazid - metabolism Isoniazid - pharmacology Mechanisms of Action: Physiological Effects Medical sciences Mycobacterium bovis - metabolism Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - metabolism Nitric Oxide Nitric Oxide - metabolism Oxidoreductases Oxidoreductases - genetics Oxidoreductases - metabolism Oxidoreductases - physiology Peroxidase - metabolism Peroxynitrous Acid - metabolism Pharmacology. Drug treatments Prodrugs - metabolism Prodrugs - pharmacology Spin Trapping Tyrosine Tyrosine - analogs & derivatives Tyrosine - metabolism Mycobacterium tuberculosis Mycobacteriales Nitric oxide Mycobacteriaceae Bacteria Actinomycetes Activation Antituberculous agent Antibacterial agent Isoniazid
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Deceased. Corresponding author. Mailing address: College of Pharmacy, University of New Mexico Health Sciences Center, Albuquerque, NM 87131. Phone: (505) 272-4103. Fax: (505) 272-6749. E-mail: gtimmins@salud.unm.edu.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.48.8.3006-3009.2004