Alkylglycerol Prodrugs of Phosphonoformate Are Potent In Vitro Inhibitors of Nucleoside-Resistant Human Immunodeficiency Virus Type 1 and Select for Resistance Mutations That Suppress Zidovudine Resistance

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 45; no. 6; pp. 1621 - 1628
Main Authors:	HAMMOND, Jennifer L, KOONTZ, Dianna L, BAZMI, Holly Z, BEADLE, James R, HOSTETLER, Saskia E, KINI, Ganesh D, ALDERN, Kathy A, RICHMAN, Douglas D, HOSTETLER, Karl Y, MELLORS, John W
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-06-2001
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Biological and medical sciences Drug Resistance, Microbial Foscarnet Foscarnet - analogs & derivatives Foscarnet - pharmacology HIV-1 HIV-1 - drug effects HIV-1 - genetics Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Prodrugs Prodrugs - pharmacology Reverse Transcriptase Inhibitors Reverse Transcriptase Inhibitors - pharmacology Structure-Activity Relationship Virion - genetics Zidovudine Zidovudine - pharmacology RNA-directed DNA polymerase Enzyme Transferases Foscarnet sodium Genetic variant Retroviridae Enzyme inhibitor Prodrug Lentivirus Biological activity Virus Resistance Nucleotidyltransferases Sensitivity resistance Dideoxynucleoside Reverse transcriptase inhibitor Antiviral Nucleoside Mutation Human immunodeficiency virus Conjugated compound Pyrimidine nucleoside Zidovudine
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Corresponding author. Mailing address: 818 Scaife Hall, School of Medicine, University of Pittsburgh, 3550 Terrace St., Pittsburgh, PA 15261. Phone: (412) 624-8512. Fax: (412) 383-7982. E-mail: mellors@msx.dept-med.pitt.edu.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.45.6.1621-1628.2001