Comparative Efficacies of Artemisinin Combination Therapies in Plasmodium falciparum Malaria and Polymorphism of pfATPase6, pfcrt, pfdhfr, and pfdhps Genes in Tea Gardens of Jalpaiguri District, India

• Published in: Antimicrobial Agents and Chemotherapy Vol. 56; no. 5; pp. 2511 - 2517
• Main Authors: SAHA, Pabitra, GUHA, Subhasish K, RAY, Krishnangshu, MAJI, Ardhendu K, DAS, Sonali, MULLICK, Shrabanee, GANGULY, Swagata, BISWAS, Asit, BERA, Dilip K, CHATTOPADHYAY, Gaurangadeb, DAS, Madhusudan, KUNDU, Pratip K
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-05-2012
• Subjects: Adolescent; Adult; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antimalarials - administration & dosage; Antimalarials - therapeutic use; Artemether, Lumefantrine Drug Combination; Artemisinins; Artemisinins - administration & dosage; Artemisinins - therapeutic use; Artesunate; Biological and medical sciences; Biomarkers - metabolism; Calcium-Transporting ATPases - genetics; Calcium-Transporting ATPases - metabolism; Child; Child, Preschool; Clinical Therapeutics; Dihydropteroate Synthase - genetics; Dihydropteroate Synthase - metabolism; Drug Combinations; Ethanolamines; Ethanolamines - administration & dosage; Ethanolamines - therapeutic use; Female; Fluorenes; Fluorenes - administration & dosage; Fluorenes - therapeutic use; Follow-Up Studies; Human protozoal diseases; Humans; India; Infectious diseases; Malaria; Malaria, Falciparum; Malaria, Falciparum - drug therapy; Malaria, Falciparum - parasitology; Male; Medical sciences; Mefloquine; Mefloquine - administration & dosage; Mefloquine - therapeutic use; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Mutation; Parasitic diseases; Pharmacology. Drug treatments; Plasmodium falciparum; Plasmodium falciparum - drug effects; Plasmodium falciparum - genetics; Polymorphism, Genetic; Protozoal diseases; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Pyrimethamine - administration & dosage; Pyrimethamine - therapeutic use; Sulfadoxine - administration & dosage; Sulfadoxine - therapeutic use; Tetrahydrofolate Dehydrogenase - genetics; Tetrahydrofolate Dehydrogenase - metabolism; Treatment Outcome; Asia; India; Protozoa; Antimalarial; Apicomplexa; Protozoal disease; Drug combination; Genetic variability; Malaria; Treatment efficiency; Artemisinin; Genotype; Parasitosis; Infection; Plasmodium falciparum; Tea; Gene; Parasiticide; Genetics; Combined treatment; Comparative study; Polymorphism
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.05388-11

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