Eukaryotic chromosome DNA replication: where, when, and how?

Eukaryotic chromosome DNA replication: where, when, and how?

DNA replication is central to cell proliferation. Studies in the past six decades since the proposal of a semiconservative mode of DNA replication have confirmed the high degree of conservation of the basic machinery of DNA replication from prokaryotes to eukaryotes. However, the need for replicatio...

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Bibliographic Details
Published in:Annual review of biochemistry Vol. 79; no. 1; pp. 89 - 130
Main Authors: Masai, Hisao, Matsumoto, Seiji, You, Zhiying, Yoshizawa-Sugata, Naoko, Oda, Masako
Format: Journal Article
Language:English
Published: United States Annual Reviews, Inc 01-01-2010
Subjects:
Animals
Chromosomes
Chromosomes - metabolism
Deoxyribonucleic acid
DNA
DNA Replication
Eukaryotes
Humans
Replication Origin
S Phase
Studies
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Summary:DNA replication is central to cell proliferation. Studies in the past six decades since the proposal of a semiconservative mode of DNA replication have confirmed the high degree of conservation of the basic machinery of DNA replication from prokaryotes to eukaryotes. However, the need for replication of a substantially longer segment of DNA in coordination with various internal and external signals in eukaryotic cells has led to more complex and versatile regulatory strategies. The replication program in higher eukaryotes is under a dynamic and plastic regulation within a single cell, or within the cell population, or during development. We review here various regulatory mechanisms that control the replication program in eukaryotes and discuss future directions in this dynamic field.
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ObjectType-Review-1
ISSN:0066-4154
1545-4509
DOI:10.1146/annurev.biochem.052308.103205