[1N,12N]Bis(Ethyl)-cis-6,7-Dehydrospermine: a New Drug for Treatment and Prevention of Cryptosporidium parvum Infection of Mice Deficient in T-Cell Receptor Alpha

• Published in: Antimicrobial Agents and Chemotherapy Vol. 44; no. 10; pp. 2891 - 2894
• Main Authors: Waters, W.R, Frydman, B, Marton, L.J, Valasinas, A, Reddy, V.K, Harp, J.A, Wannemuehler, M.J, Yarlett, N
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-10-2000
• Series: Note
• Subjects: (N,N)bis(ethyl)-6,7-dehydrospermine; [@u1N,@@u12@N]bis(ethyl)-cis-6,7-dehydrospermine; acute course; animal disease models; animal health; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiparasitic agents; Antiprotozoal Agents; Antiprotozoal Agents - therapeutic use; biochemical pathways; Biological and medical sciences; bis(ethyl)-cis-dehydrospermine; cecum; Cecum - parasitology; Cecum - pathology; chronic diseases; Cryptosporidiosis; Cryptosporidiosis - drug therapy; Cryptosporidiosis - parasitology; Cryptosporidiosis - prevention & control; Cryptosporidium parvum; dehydrospermine; diarrhea; disease control; disease prevention; drug therapy; Experimental Therapeutics; Genes, T-Cell Receptor alpha; Genes, T-Cell Receptor alpha - genetics; histopathology; human health; immunosuppression (physiological); Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; new drugs; oral administration; persistent infections; Pharmacology. Drug treatments; protozoal infections; putrescine; Putrescine - pharmacology; SL-11047; Spermine; Spermine - analogs & derivatives; Spermine - therapeutic use; T-cell receptor alpha-chain; T-lymphocytes; Protozoa; Apicomplexa; Polyamine; Rodentia; Putrescine; Prevention; Vertebrata; Mammalia; Spermine; Cryptosporidium parvum; Mouse; Analog; Animal; Parasiticid; T-Lymphocyte; Biological receptor
• ISSN: 1098-6596; 0066-4804; 1098-6596
• DOI: 10.1128/AAC.44.10.2891-2894.2000

Cryptosporidium parvum infection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) prevented C. parvum infection in suckling TCR-α-deficient mice and cleared an existing infection in older mice. Treatment with putrescine, while capable of preventing infection, did not clear C. parvum from previously infected mice. These findings provide further evidence that polyamine metabolic pathways are targets for new anticryptosporidial chemotherapeutic agents.