Synthetic reverberating activity patterns embedded in networks of cortical neurons

• Main Authors: Vardi, Roni, Wallach, Avner, Kopelowitz, Evi, Abeles, Moshe, Marom, Shimon, Kanter, Ido
• Format: Journal Article
• Language: English
• Published: 26-03-2012
• Subjects: Physics - Chaotic Dynamics; Quantitative Biology - Neurons and Cognition
• DOI: 10.48550/arxiv.1201.0339

EPL (Europhysics Letters) 97, 66002 (2012) Synthetic reverberating activity patterns are experimentally generated by
stimulation of a subset of neurons embedded in a spontaneously active network
of cortical cells in-vitro. The neurons are artificially connected by means of
conditional stimulation matrix, forming a synthetic local circuit with a
predefined programmable connectivity and time-delays. Possible uses of this
experimental design are demonstrated, analyzing the sensitivity of these
deterministic activity patterns to transmission delays and to the nature of
ongoing network dynamics.