MicroRNA-155 and Its Role in Malignant Hematopoiesis
MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and malignant hematopoiesis. It has been found to be involved in the pathogenesis of many different hematological malignancies with either an oncogenic or a tumor-repressor effect, depending on the nature of the cell and th...
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| Published in: | Biomarker Insights Vol. 2015; no. 10; pp. 95 - 102 |
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| Main Author: | |
| Format: | Journal Article Book Review |
| Language: | English |
| Published: |
London, England
Libertas Academica
01-01-2015
SAGE Publishing SAGE Publications |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | MicroRNA-155 (miR-155) is a multifunctional molecule involved in both normal and
malignant hematopoiesis. It has been found to be involved in the pathogenesis of
many different hematological malignancies with either an oncogenic or a
tumor-repressor effect, depending on the nature of the cell and the type of
malignancy. In particular, it has been strongly implicated in the causation of
diffuse large B-cell lymphomas. This review focuses on the molecular
interactions of miR-155, its oncogenic mechanisms, and its potential as an
effective therapeutic target for the associated malignancies. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 1177-2719 1177-2719 |
| DOI: | 10.4137/BMI.S27676 |