Pharmacokinetic profile of ABELCET (amphotericin B lipid complex injection): combined experience from phase I and phase II studies

• Published in: Antimicrobial Agents and Chemotherapy Vol. 41; no. 10; pp. 2201 - 2208
• Main Authors: ADEDOYIN, A, BERNARDO, J. F, ANAISSIE, E, LOPEZ-BERESTEIN, G, LLANOS-CUENTAS, A, BOYLE, A, BRANCH, R. A, SWENSON, C. E, BOLSACK, L. E, HORWITH, G, DEWIT, S, KELLY, E, KLASTERKSY, J, SCULIER, J. P, DEVALERIOLA, D
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01-10-1997
• Subjects: Amphotericin B; Amphotericin B - administration & dosage; Amphotericin B - blood; Amphotericin B - pharmacokinetics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal Agents; Antifungal Agents - administration & dosage; Antifungal Agents - blood; Antifungal Agents - pharmacokinetics; Antineoplastic Agents - adverse effects; Area Under Curve; Biological and medical sciences; Chromatography, High Pressure Liquid; Clinical Trial; Clinical Trial, Phase I; Clinical Trial, Phase II; Drug Combinations; Drug Interactions; Half-Life; HIV Infections - metabolism; Humans; Kidney Diseases - metabolism; Leishmaniasis, Mucocutaneous - metabolism; Medical sciences; Mycoses - metabolism; Neutropenia - metabolism; Pharmacology. Drug treatments; Phosphatidylcholines; Phosphatidylcholines - administration & dosage; Phosphatidylcholines - blood; Phosphatidylcholines - pharmacokinetics; Phosphatidylglycerols; Phosphatidylglycerols - administration & dosage; Phosphatidylglycerols - blood; Phosphatidylglycerols - pharmacokinetics; Reference Values; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S; Antineoplastic agent; Mycosis; Toxicity; Lipids; Drug carrier; Antifungal agent; Formulation; Secondary effect; Lentivirinae; Complication; Drug interaction; Human; Kidney disease; Immunopathology; Drug combination; Urinary system disease; Pharmaceutical technology; Retroviridae; Liposome; Suspension; Drug adjuvant; Immune deficiency; Infection; Virus; Amphotericin B; Polyenic compound; Interindividual comparison; Dosage form; Human immunodeficiency virus; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/aac.41.10.2201

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