Attenuation of Colistin Bactericidal Activity by High Inoculum of Pseudomonas aeruginosa Characterized by a New Mechanism-Based Population Pharmacodynamic Model

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Published in:	Antimicrobial Agents and Chemotherapy Vol. 54; no. 5; pp. 2051 - 2062
Main Authors:	BULITTA, Jürgen B, YANG, Jenny C, YOHONN, Liliana, LY, Neang S, BROWN, Silvia V, D'HONDT, Rebecca E, JUSKO, William J, FORREST, Alan, TSUJI, Brian T
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-05-2010 American Society for Microbiology (ASM)
Subjects:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacokinetics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria Bacterial Outer Membrane Proteins - metabolism Binding, Competitive Biological and medical sciences Calcium - metabolism Colistin Colistin - pharmacokinetics Drug Resistance, Bacterial Experimental Therapeutics In Vitro Techniques Magnesium - metabolism Medical sciences Microbial Sensitivity Tests Models, Biological Pharmacology. Drug treatments Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development Pseudomonas aeruginosa - metabolism Pseudomonadales Pharmacodynamics Colistin Cyclic peptides Biological activity Antibiotic Polypeptide Bacteria Pseudomonadaceae Pseudomonas aeruginosa Models Antibacterial agent Mechanism of action Public health
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Summary:	Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue AAC About AAC Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AAC RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0066-4804 Online ISSN: 1098-6596 Copyright © 2014 by the American Society for Microbiology. For an alternate route to AAC .asm.org, visit: AAC
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 J.B.B. and J.C.Y. contributed equally to this project. Present address: Translational Sciences (TMSO), Novartis Institutes for BioMedical Research, East Hanover, NJ.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00881-09