Determinants and Functions of Mitochondrial Behavior

• Published in: Annual review of cell and developmental biology Vol. 30; no. 1; pp. 357 - 391
• Main Authors: Labbé, Katherine, Murley, Andrew, Nunnari, Jodi
• Format: Journal Article
• Language: English
• Published: United States Annual Reviews 01-01-2014
• Subjects: Animals; autophagy; DNA, Mitochondrial - metabolism; Dynamins - physiology; Endoplasmic Reticulum - physiology; GTP Phosphohydrolases - physiology; Homeostasis; Humans; Lipid Metabolism; Microtubule-Associated Proteins - physiology; Mitochondria - physiology; Mitochondrial Diseases - physiopathology; mitochondrial dynamics; Mitochondrial Membranes - metabolism; mitochondrial motility; Mitochondrial Proteins - physiology; mitochondrial tethering; Mitochondrial Turnover - physiology; mitophagy; mtDNA; Protein Conformation; Signal Transduction - physiology; mitophagy; autophagy; mitochondrial tethering; mtDNA; mitochondrial motility; mitochondrial dynamics
• ISSN: 1081-0706; 1530-8995
• DOI: 10.1146/annurev-cellbio-101011-155756

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the behavior of mitochondria inside eukaryotic cells has changed dramatically, and the corresponding machineries that control it are in most cases new inventions. The evolution of mitochondrial behavior reflects the necessity to create a dynamic compartment to integrate the myriad mitochondrial functions with the status of other endomembrane compartments, such as the endoplasmic reticulum, and with signaling pathways that monitor cellular homeostasis and respond to stress. Here we review what has been discovered about the molecular machineries that work together to control the collective behavior of mitochondria in cells, as well as their physiological roles in healthy and disease states.