MicroRNAs in Cancer

MicroRNAs in Cancer

MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several...

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Bibliographic Details
Published in:Annual review of medicine Vol. 60; no. 1; pp. 167 - 179
Main Authors: Garzon, Ramiro, Calin, George A, Croce, Carlo M
Format: Journal Article
Language:English
Published: United States Annual Reviews, Inc 01-01-2009
Subjects:
Animals
Apoptosis
Cancer
Cell cycle
Epigenesis, Genetic
Genes, Tumor Suppressor - physiology
Humans
Medical diagnosis
Medical prognosis
MicroRNAs - physiology
Neoplasms - genetics
Oncogenes - physiology
Oncology
Prognosis
Ribonucleic acid
RNA
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Summary:MicroRNAs (miRNAs) are small, noncoding RNAs with important functions in development, cell differentiation, and regulation of cell cycle and apoptosis. MiRNA expression is deregulated in cancer by a variety of mechanisms including amplification, deletion, mutation, and epigenetic silencing. Several studies have now shown that miRNAs are involved in the initiation and progression of cancer. In this review, we briefly describe miRNA biogenesis and discuss how miRNAs can act as oncogenes and tumor suppressors. We also address the role of miRNAs in the diagnosis, prognosis, and treatment of cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.med.59.053006.104707