Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

Enantioselective Synthesis of a Novel Thiazoline Core as a Potent Peroxisome Proliferator-Activated Receptor δ Agonist

The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiot...

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Bibliographic Details
Published in:ACS omega Vol. 3; no. 2; pp. 1970 - 1976
Main Authors: Lee, Su-Jeong, Samala, Mallesham, Woo, Seo Yeon, Hahn, Dongyup, Kim, Dayoung, Kadayat, Tara Man, Jung, Kyungjin, Kim, Jina, Kim, Dong-Su, Kwon, Sugyeong, Kim, Shinae, Kim, Kyung-Hee, Nam, Sang-Jip, Cho, Sung Jin, Chin, Jungwook
Format: Journal Article
Language:English
Published: United States American Chemical Society 28-02-2018
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Summary:The convergent and enantioselective synthesis of a highly potent human peroxisome proliferator-activated receptor delta agonist is presented. More specifically, the thiazoline structure, which constitutes the biosynthetically distinctive core structure of pulicatin (a secondary metabolite of symbiotic bacteria), was synthesized from a commercially available and inexpensive chiral pool of l-threonine.
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ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.7b01689