Green Method for the Synthetic Ugi Reaction by Twin Screw Extrusion without a Solvent and Catalyst

Green Method for the Synthetic Ugi Reaction by Twin Screw Extrusion without a Solvent and Catalyst

This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solv...

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Bibliographic Details
Published in:ACS omega Vol. 5; no. 11; pp. 6194 - 6198
Main Authors: Ali El-Remaily, Mahmoud Abd El Aleem Ali, Soliman, Ahmed M. M, Elhady, Omar M
Format: Journal Article
Language:English
Published: United States American Chemical Society 24-03-2020
Online Access:Get full text
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Summary:This study describes the solvent and catalyst-free Ugi reaction by way of twin screw extrusion (TSE). Multicomponent chemical synthesis can be converted into a single process without repeated use of solvents through TSE. High synthetic yields are achieved in short reaction times and produced in solvent-free conditions, which lead to a more environmentally friendly process.
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ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.0c00369