Adapting Smoking Cessation Treatment According to Initial Response to Precessation Nicotine Patch

• Published in: The American journal of psychiatry Vol. 170; no. 8; pp. 860 - 867
• Main Authors: Rose, Jed E., Behm, Frédérique M.
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Association 01-08-2013
• Subjects: Addictive behaviors; Adult; Adult and adolescent clinical studies; Benzazepines - administration & dosage; Benzazepines - adverse effects; Biological and medical sciences; Bupropion - administration & dosage; Bupropion - adverse effects; Clinical outcomes; Combined Modality Therapy; Desintoxication. Drug withdrawal; Dopamine Uptake Inhibitors - administration & dosage; Dopamine Uptake Inhibitors - adverse effects; Double-Blind Method; Drug Synergism; Drug therapy; Female; Humans; Male; Medical sciences; Middle Aged; Nicotinic Agonists - administration & dosage; Nicotinic Agonists - adverse effects; Pharmacology; Premedication; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Quinoxalines - administration & dosage; Quinoxalines - adverse effects; Smoking cessation; Smoking Cessation - methods; Tobacco smoking; Tobacco Use Cessation Products - adverse effects; Tobacco Use Disorder - therapy; Tobacco, tobacco smoking; Toxicology; Treatment Outcome; Treatments; Varenicline; Alkaloid; Poison withdrawal; Treatment; Patch; Tobacco smoking; Nicotine
• ISSN: 0002-953X; 1535-7228
• DOI: 10.1176/appi.ajp.2013.12070919

Smokers who can’t reduce their cigarette intake using precessation nicotine patch treatment can benefit from alternative therapies, such as augmenting the patch with bupropion or switching to varenicline. An adaptive treatment plan can increase smoking cessation rates while minimizing risks and side effects.
ObjectiveThe authors evaluated an adaptive smoking cessation treatment strategy in which nicotine patch treatment was initiated before a quit date, and then, depending on initial therapeutic response, either the nicotine patch was continued or alternative pharmacotherapies were provided.MethodThe study was a double-blind, parallel-arm adaptive treatment trial. A total of 606 cigarette smokers started open-label nicotine patch treatment 2 weeks before the quit date. Those whose ad lib smoking did not decrease by >50% after 1 week were randomly assigned to one of three double-blind treatments: nicotine patch alone (control condition); “rescue” treatment with bupropion augmentation of the patch; or rescue treatment with varenicline alone. Participants whose precessation smoking decreased >50% but who lapsed after the quit date were also randomly assigned to the two rescue treatments or to nicotine patch alone. Logistic regression analyses compared each rescue treatment against the control condition in terms of abstinence at the end of treatment (weeks 8–11) and at 6 months.ResultsSmokers who did not respond adequately to precessation nicotine patch benefited from bupropion augmentation; abstinence rates at end of treatment were 16% with nicotine patch alone and 28% with bupropion augmentation (odds ratio=2.04, 95% CI=1.03–4.01). Switching to varenicline produced less robust effects, but point abstinence at 6 months was 6.6% with the patch alone and 16.5% with a switch to varenicline (odds ratio=2.80, 95% CI=1.11–7.06). Postquit adaptive changes in treatment had no significant effects on any abstinence outcome.ConclusionsIt is possible to rescue a significant portion of smokers who would have failed to achieve abstinence if left on nicotine patch alone by identifying these smokers before their quit date and implementing adaptive changes in treatment.