Ductal and Acinar Adenocarcinoma of Prostate Morphological and Immunohistochemical Characterization

• Published in: Oman medical journal Vol. 30; no. 3; pp. 162 - 166
• Main Authors: Syed , Serajuddaula, Baig , Faraz A, Hamid , Amna, Mirza , Talat
• Format: Journal Article
• Language: English
• Published: Muscat - Oman Oman Medical Specialty Board 01-05-2015; OMJ
• Subjects: Acinar Carcinoma; Adenocarcinoma; Cancer; Diagnosis; Ductal Carcinoma; Gleason Score; IMMUNITY; Immunohistochemistry; MALE GENITAL SYSTEM; MEDICAL SCIENCES; NEOPLASMS; Original; PROSTATE; PROSTATITIS; إلتهاب البروستات; الأورام; البروستات; الجهاز التناسلي الذكري; العلوم الطبية; المناعة; Adenocarcinoma; Immunohistochemistry; Gleason Score; Ductal Carcinoma; Prostate; Acinar Carcinoma
• ISSN: 1999-768X; 2070-5204
• DOI: 10.5001/omj.2015.36

Objectives: We sought to characterize the ductal and acinar subtype of prostate
adenocarcinoma using hematoxylin and eosin (H&E) staining and an immunohistochemical
antibody cocktail. We also investigated the clinical features, prostate-specific antigen (PSA)
levels, and biological aggressiveness of these tumors. Methods: We utilized tumor bearing
prostate biopsies, obtained between 2010 and 2014 from Dow Diagnostic Research and
Reference Laboratory, to identify cases of prostatic ductal and acinar adenocarcinoma using
routine H&E and immunohistochemical staining. The immunohistochemical antibody
cocktail 34βE12/p63/AMACR was used for staining. The association of clinicopathological
variables including patient’s age at diagnosis, Gleason score, and PSA levels before surgery
was retrospectively analyzed. Results: A total of 10 ductal and 140 non-ductal cases were
identified. Ductal cases were predominantly high grade with advanced histopathological
features (90%; p=0.030). Marked elevation in PSA level was also reported in most cases.
No other significant statistical difference was observed. Conclusions: Pathological and
immunohistochemical examination could be used to characterize ductal and acinar
adenocarcinoma of the prostate. Ductal adenocarcinoma of the prostate is a rare subtype of
prostate carcinoma and is be more likely to present with advanced grade cancer suggesting
that timely detection of the disease is vital.