A Perspective on Late-Stage Aromatic C–H Bond Functionalization
Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspecti...
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| Published in: | Journal of the American Chemical Society Vol. 144; no. 6; pp. 2399 - 2414 |
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| Main Authors: | , |
| Format: | Journal Article |
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16-02-2022
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| Abstract | Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C–H LSF on the basis of four criteriareactivity, chemoselectivity, site-selectivity, and substrate scopeand provide our own views on current challenges as well as promising strategies and areas of growth going forward. |
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| AbstractList | Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward. Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward.Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C-H LSF is challenging because the C-H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C-H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward. Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C–H LSF on the basis of four criteria—reactivity, chemoselectivity, site-selectivity, and substrate scope—and provide our own views on current challenges as well as promising strategies and areas of growth going forward. Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C–H LSF on the basis of four criteriareactivity, chemoselectivity, site-selectivity, and substrate scopeand provide our own views on current challenges as well as promising strategies and areas of growth going forward. |
| Author | Zhang, Li Ritter, Tobias |
| Author_xml | – sequence: 1 givenname: Li orcidid: 0000-0002-3849-1664 surname: Zhang fullname: Zhang, Li – sequence: 2 givenname: Tobias orcidid: 0000-0002-6957-450X surname: Ritter fullname: Ritter, Tobias email: ritter@mpi-muelheim.mpg.de |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35084173$$D View this record in MEDLINE/PubMed |
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| Snippet | Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules.... Late-stage functionalization of C-H bonds (C-H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules.... Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules.... |
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| Title | A Perspective on Late-Stage Aromatic C–H Bond Functionalization |
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