A Perspective on Late-Stage Aromatic C–H Bond Functionalization

A Perspective on Late-Stage Aromatic C–H Bond Functionalization

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspecti...

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Bibliographic Details
Published in:Journal of the American Chemical Society Vol. 144; no. 6; pp. 2399 - 2414
Main Authors: Zhang, Li, Ritter, Tobias
Format: Journal Article
Language:English
Published: United States American Chemical Society 16-02-2022
Online Access:Get full text
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Summary:Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C–H LSF on the basis of four criteriareactivity, chemo­selectivity, site-selectivity, and substrate scopeand provide our own views on current challenges as well as promising strategies and areas of growth going forward.
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ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.1c10783