Mycgranol, a New Diterpene from the Marine Sponge Mycale aff. graveleyi

• Published in: Journal of natural products (Washington, D.C.) Vol. 68; no. 2; pp. 280 - 281
• Main Authors: Rudi, Amira, Benayahu, Yehuda, Kashman, Yoel
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01-02-2005; Glendale, AZ American Society of Pharmacognosy
• Subjects: Aegogropila; Aegogropila graveleyi; Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Diterpenes - chemistry; Diterpenes - classification; Diterpenes - isolation & purification; Fundamental and applied biological sciences. Psychology; Kenya; Marine; Molecular Structure; Mycale; Mycale graveleyi; Nuclear Magnetic Resonance, Biomolecular; Other biological molecules; Porifera - chemistry; Spongia; Terpenes, steroids. Hormones; Kenya; Africa; ISW, Kenya, Coast; Marine environment; Terpenoid; Porifera; Absolute configuration; Diterpene; Animal origin; Isolation; Sponge; Invertebrata; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0497550

Mycgranol, a new isocopalane diterpene (methyl 1β-hydroxy-2-oxoisocopalanoate) was isolated from the Kenyan sponge Mycale (Aegogropila) aff. graveleyi. The structure of the compound was elucidated by interpretation of MS, COSY, HMQC, HMBC, and ROESY data. The absolute configuration of mycgranol was determined to be the same as that of the nudibranch isocopalane diterpenes rather than that of the ent-compounds known from sponges of the genus Spongia.