Phaeosphaeride A, an Inhibitor of STAT3-Dependent Signaling Isolated from an Endophytic Fungus
Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.
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| Published in: | Organic letters Vol. 8; no. 18; pp. 4067 - 4070 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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American Chemical Society
31-08-2006
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| Abstract | Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3. |
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| AbstractList | Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3. |
| Author | Brady, Sean F Hao, Wenshan Roll, Deborah Hucul, John Schroeder, Frank C Xu, Jun Gibbons, Jay Clardy, Jon Maloney, Katherine N |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16928075$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1158/0008-5472.CAN-03-3959 10.1158/1535-7163.MCT-05-0268 10.1021/ja00220a085 10.1002/(SICI)1097-0215(20000301)85:5<720::AID-IJC20>3.0.CO;2-O 10.1021/np50095a012 10.1016/S0092-8674(00)81959-5 |
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| Notes | Department of Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School. Department of Discovery Oncology, Wyeth Research, Pearl River, NY 10965, USA. |
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| Snippet | Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3. |
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| SubjectTerms | Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line, Tumor Fungi - metabolism Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - metabolism Heterocyclic Compounds, 2-Ring - pharmacology Humans Inhibitory Concentration 50 Molecular Structure Signal Transduction - drug effects STAT3 Transcription Factor - antagonists & inhibitors |
| Title | Phaeosphaeride A, an Inhibitor of STAT3-Dependent Signaling Isolated from an Endophytic Fungus |
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