Phaeosphaeride A, an Inhibitor of STAT3-Dependent Signaling Isolated from an Endophytic Fungus

Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.

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Bibliographic Details
Published in:	Organic letters Vol. 8; no. 18; pp. 4067 - 4070
Main Authors:	Maloney, Katherine N, Hao, Wenshan, Xu, Jun, Gibbons, Jay, Hucul, John, Roll, Deborah, Brady, Sean F, Schroeder, Frank C, Clardy, Jon
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 31-08-2006
Subjects:	Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Bridged Bicyclo Compounds, Heterocyclic - chemistry Bridged Bicyclo Compounds, Heterocyclic - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line, Tumor Fungi - metabolism Heterocyclic Compounds, 2-Ring - chemistry Heterocyclic Compounds, 2-Ring - metabolism Heterocyclic Compounds, 2-Ring - pharmacology Humans Inhibitory Concentration 50 Molecular Structure Signal Transduction - drug effects STAT3 Transcription Factor - antagonists & inhibitors
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Description
Summary:	Phaeosphaeride A, a nitrogen-containing bicyclic compound produced by an endophytic fungus, inhibits signaling by the transcription factor STAT3.
Bibliography:	Department of Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School. Department of Discovery Oncology, Wyeth Research, Pearl River, NY 10965, USA.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol061556f