Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant Pseudomonas aeruginosa

Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant Pseudomonas aeruginosa

In some cases, colistin is the only treatment option for infections caused by the very drug-resistant . However, in the past decade, there have been questions concerning its pharmacokinetics and concentration at the site of infection. In this scenario, its use in a difficult-to-treat infection like...

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Bibliographic Details
Published in:Microbiology spectrum Vol. 11; no. 6; p. e0296723
Main Authors: Sorlí, Luisa, Luque, Sonia, Li, Jian, Benítez-Cano, Adela, Fernández, Xenia, Prim, Nuria, Vega, Victoria, Gómez-Junyent, Joan, López-Montesinos, Inmaculada, Gómez-Zorrilla, Silvia, Montero, M Milagro, Grau, Santiago, Horcajada, Juan Pablo
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 12-12-2023
Subjects:
Antimicrobial Chemotherapy
colistin
pharmacokinetics
pneumonia
Pseudomonas aeruginosa
Research Article
pharmacokinetics
Pseudomonas aeruginosa
pneumonia
colistin
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Summary:In some cases, colistin is the only treatment option for infections caused by the very drug-resistant . However, in the past decade, there have been questions concerning its pharmacokinetics and concentration at the site of infection. In this scenario, its use in a difficult-to-treat infection like pneumonia is currently debatable. This is a clinical pharmacokinetic study of colistin in patients with multidrug-resistant P. aeruginosa pneumonia. Our findings demonstrate that colistin exposure is associated with worse clinical outcomes rather than better clinical outcomes, implying that other therapeutic options should be explored in this clinical setting.
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Luisa Sorlí and Sonia Luque contributed equally to this article. The clinical profile of the publication was taken into consideration to determine author order.
The authors declare no conflict of interest.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.02967-23