Examining the Association between Body Burdens of Harmful Chemicals and Heaviness of Marijuana Smoking

Marijuana is seeing increased use both globally and domestically. However, the scientific community has not fully reached a consensus about what negative health effects and to what extent marijuana smoking may cause. In this study, we evaluated the associations between the body burdens of polycyclic...

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Bibliographic Details
Published in:	Chemical research in toxicology Vol. 31; no. 8; pp. 643 - 645
Main Authors:	Wei, Binnian, Smith, Danielle, O’Connor, Richard, Travers, Mark J, Hyland, Andrew
Format:	Journal Article
Language:	English
Published:	United States American Chemical Society 20-08-2018
Subjects:	Adult Body Burden Chromatography, High Pressure Liquid Female Humans Male Marijuana Smoking - adverse effects Polycyclic Aromatic Hydrocarbons - analysis Polycyclic Aromatic Hydrocarbons - pharmacokinetics Tandem Mass Spectrometry
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Summary:	Marijuana is seeing increased use both globally and domestically. However, the scientific community has not fully reached a consensus about what negative health effects and to what extent marijuana smoking may cause. In this study, we evaluated the associations between the body burdens of polycyclic aromatic hydrocarbons (PAHs) among marijuana smokers and the smoking heaviness. We observed clear, increasing trends of PAH body burdens as marijuana smoking increased. The findings highlight the importance of capturing the heaviness of marijuana smoking in future studies and support the need for well-designed toxicological and epidemiological studies for understanding the health effects of marijuana use in a changing environment.
Bibliography:	Dr. Wei had full access to all of the data in the study and takes full responsibility for the integrity of the data and the accuracy of the data analysis; Study concept and design: Wei, Hyland; Interpretation of data: Wei, Hyland, O’Connor, Travers, Smith; Draft of the manuscript: Wei; Critical revision of the manuscript for important intellectual content: Wei, Hyland, O’Connor, Travers, Smith; Statistical analysis: Wei, O’Connor, Smith; Study supervision: Hyland. Author Contributions
ISSN:	0893-228X 1520-5010
DOI:	10.1021/acs.chemrestox.8b00160