In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against spor...

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Published in:Antimicrobial agents and chemotherapy Vol. 59; no. 8; pp. 5018 - 5021
Main Authors: Mario, Débora Nunes, Guarro, Josep, Santurio, Janio Morais, Alves, Sydney Hartz, Capilla, Javier
Format: Journal Article
Language:English
Published: United States American Society for Microbiology 01-08-2015
Subjects:
Amphotericin B
Amphotericin B - therapeutic use
Animals
Antifungal Agents
Antifungal Agents - therapeutic use
Drug Resistance, Multiple, Fungal
Drug Therapy, Combination
Mice
Microbial Sensitivity Tests
Pharmacology
Sporothrix
Sporothrix - drug effects
Sporothrix - pathogenicity
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - drug therapy
Triazoles
Triazoles - therapeutic use
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Abstract We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
AbstractList We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto . In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
Author Alves, Sydney Hartz
Santurio, Janio Morais
Guarro, Josep
Mario, Débora Nunes
Capilla, Javier
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Citation Mario DN, Guarro J, Santurio JM, Alves SH, Capilla J. 2015. In vitro and in vivo efficacy of amphotericin B combined with posaconazole against experimental disseminated sporotrichosis. Antimicrob Agents Chemother 59:5018–5021. doi:10.1128/AAC.00052-15.
Present address: Débora Nunes Mario, Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
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Snippet We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and...
We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and...
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StartPage 5018
SubjectTerms Amphotericin B
Amphotericin B - therapeutic use
Animals
Antifungal Agents
Antifungal Agents - therapeutic use
Drug Resistance, Multiple, Fungal
Drug Therapy, Combination
Mice
Microbial Sensitivity Tests
Pharmacology
Sporothrix
Sporothrix - drug effects
Sporothrix - pathogenicity
Sporothrix schenckii
Sporotrichosis
Sporotrichosis - drug therapy
Triazoles
Triazoles - therapeutic use
Title In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis
URI https://www.ncbi.nlm.nih.gov/pubmed/26014930
https://journals.asm.org/doi/10.1128/AAC.00052-15
https://search.proquest.com/docview/1697215021
https://search.proquest.com/docview/1709173877
https://pubmed.ncbi.nlm.nih.gov/PMC4505257
Volume 59
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