In Vitro and In Vivo Efficacy of Amphotericin B Combined with Posaconazole against Experimental Disseminated Sporotrichosis

We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against spor...

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Bibliographic Details
Published in:	Antimicrobial agents and chemotherapy Vol. 59; no. 8; pp. 5018 - 5021
Main Authors:	Mario, Débora Nunes, Guarro, Josep, Santurio, Janio Morais, Alves, Sydney Hartz, Capilla, Javier
Format:	Journal Article
Language:	English
Published:	United States American Society for Microbiology 01-08-2015
Subjects:	Amphotericin B Amphotericin B - therapeutic use Animals Antifungal Agents Antifungal Agents - therapeutic use Drug Resistance, Multiple, Fungal Drug Therapy, Combination Mice Microbial Sensitivity Tests Pharmacology Sporothrix Sporothrix - drug effects Sporothrix - pathogenicity Sporothrix schenckii Sporotrichosis Sporotrichosis - drug therapy Triazoles Triazoles - therapeutic use
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Summary:	We evaluated the combination of posaconazole with amphotericin B in vitro and in a murine model of systemic infections caused by Sporothrix brasiliensis and Sporothrix schenckii sensu stricto. In vitro data demonstrated a synergistic effect, and although posaconazole alone was effective against sporotrichosis, efficacy in terms of survival and burden reduction was increased with the combination. This combination might be an option against disseminated sporotrichosis, especially when itraconazole or amphotericin B at optimal doses are contraindicated.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Citation Mario DN, Guarro J, Santurio JM, Alves SH, Capilla J. 2015. In vitro and in vivo efficacy of amphotericin B combined with posaconazole against experimental disseminated sporotrichosis. Antimicrob Agents Chemother 59:5018–5021. doi:10.1128/AAC.00052-15. Present address: Débora Nunes Mario, Department of Microbiology and Parasitology, Universidade Federal de Santa Maria, Santa Maria, Brazil.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00052-15